MYELOID NEOPLASIA Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms
نویسندگان
چکیده
1Hôpital Avicenne, Assistance Publique–Hôpitaux de Paris (AP-HP), Service d’Hématologie Biologique, Bobigny, France; 2Inserm U978, Laboratoire des Adaptateurs de Signalisation en Hématologie, Bobigny, France; 3Université Paris 13, UFR SMBH, Bobigny, France; 4Inserm U972, Institut André Lwoff, Univeristé Paris XI, Hôpital Paul Brousse, Villejuif, France; 5Hôpital Avicenne, AP-HP, Service d’Hématologie Clinique, Bobigny, France; 6Hôpital Saint-Louis, Unité de Biologie Cellulaire, Paris, France; 7Hôpital Saint-Louis, Département de Biostatistique et Informatique Médicale, Paris, France; 8Laboratoire d’Hématologie, Hôpital Henri Mondor, Créteil, France; and 9Hôpital Saint-Louis, Clinical Investigation Center and French Intergroup of Myeloproliferative Disorders (FIM), Paris, France
منابع مشابه
Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.
Activating mutations in signaling molecules, such as JAK2-V617F, have been associated with myeloproliferative neoplasms (MPNs). Mice lacking the inhibitory adaptor protein Lnk display deregulation of thrombopoietin/thrombopoietin receptor signaling pathways and exhibit similar myeloproliferative characteristics to those found in MPN patients, suggesting a role for Lnk in the molecular pathogene...
متن کاملThe Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms
OBJECTIVE LNK is an adapter protein negatively regulating the JAK/STAT cell signaling pathway. In this study, we observed the correlation between variation in LNK gene and the clinical type of myeloproliferative neoplasms (MPN). METHODS A total of 285 MPN cases were recruited, including essential thrombocythemia (ET) 154 cases, polycythemia vera (PV) 76 cases, primary myelofibrosis (PMF) 19 c...
متن کامل14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.
Hematopoietic stem and progenitor cell (HSPC) functions are governed by intricate signaling networks. The tyrosine kinase JAK2 plays an essential role in cytokine signaling during hematopoiesis. The adaptor protein LNK is a critical determinant of this process through its inhibitory interaction with JAK2, thereby limiting HSPC self-renewal. LNK de...
متن کاملارزیابی جهش JAK2V617F در نئوپلاسم های میلوپرولیفراتیو کلاسیک غیر CML به روش ARMS-PCR
Background and Aim : Myeloproliferative neoplasms are clonal and heterogeneous disorders of hematopoietic stem cells lead to increase of one or more cell lines in the blood. Recently, the acquired mutation JAK2 V617F has been described in the majority of patients with myeloproliferative neoplasms (MPNs).This mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the J...
متن کاملLnk constrains myeloproliferative diseases in mice.
Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling, and activating mutations in JAK2 are found in a number of hematologic malignancies. We previously demonstrated that lymphocyte adaptor protein (Lnk, also known as Sh2b3) binds JAK2 and attenuates...
متن کامل